Abstract
Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptamine 5-HT(6) receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Binding Sites
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Drug Interactions
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Humans
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Indoles / chemistry
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Pyrrolidines / chemistry
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Receptors, Serotonin / chemistry
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Receptors, Serotonin / metabolism*
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Serotonin Antagonists / chemistry
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Serotonin Antagonists / pharmacology*
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Structure-Activity Relationship
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Tryptamines / chemistry*
Substances
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Indoles
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N1-benzenesulfonyl-5-methoxy-N,N-dimethyltryptamine
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Pyrrolidines
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Receptors, Serotonin
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Serotonin Antagonists
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Tryptamines
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serotonin 6 receptor